Background: Sublingual formulations of buprenorphine (BUP) and BUP/naloxone have well-established pharmacokinetic and pharmacodynamic profiles, and are safe and effective for treating opioid use disorder. loss of bladder control. Published Nov. Am J Addict 2014;23(3):318–9. Long-acting means that the drug acts more slowly in the body, for a longer period of time. Methadone Clinics; Suboxone Treatment; About; Get Help Now. Generally, most physical withdrawal symptoms will subside after one month,. It is prescribed when other pain medications have not worked or cannot be tolerated. The medication is available as a tablet or film that's either dissolved under your tongue or against the inside of your cheek. 13, 2023 Updated Nov. Uses. report_problem. Bampton Road. Transdermal buprenorphine to subcutaneous morphine or oxycodone infusions 12 12. Akron Dr. INTRODUCTION. Consumers in New York State who would like to find out more information about buprenorphine, or to find a doctor who prescribes buprenorphine, can call the NYS HOPEline at 1-877-8-HOPENY. New Publication. With buprenorphine, however, these effects are weaker than full. HHS. During the study period, the mobile clinic served 569 people—of these, about 74% received prescriptions for buprenorphine and 70% were tested for at least one infectious disease. Let us help you. Akron Suboxone Doctor is committed to providing high-quality care to those struggling with addiction. Call your. Recovery is possible and Cleveland Clinic Akron General Alcohol and Drug Recovery Center offers help and guidance. Journal of addiction medicine. buprenorphine increases risk of overdose death upon Try to avoid very hairy areas, or trim the hairs first before applying the patch. Dosages of transdermal buprenorphine >20 mcg/hr and buccal film >900 mcg every 12 hours should be. 8-12mg of buprenorphine Most people feel better the first day after 8-12mg. It will take about 5 minutes for it to dissolve. orgPROVIDENCE, R. Buprenorphine has a high potential for. Gov. Site visitors can search for physicians authorized to provide OUD treatment with buprenorphine. Proper Use. Nic Helmstetter crab-walked down a steep, rain-slicked trail into a grove of maple and cottonwood trees to his destination: a. Buprenorphine (pronounced 'bew-pre-nor-feen') is a prescription drug. However, Suboxone is not used to treat pain. This drug is more popular than comparable drugs. 2020 Oct;13 (10):1159-1167. Naloxone is a medicine that is available to patients for theClinical pharmacology of buprenorphine: ceiling effects at high doses. Among patients newly initiating buprenorphine treatment for opioid use disorder, 59% of those prescribed the target daily dose of 16 milligrams recommended by the U. Submit a new suboxone treatment clinic here. doses (0. This approval eliminates the need to visit specialized treatment clinics, thereby expanding access to treatment for many who need it. Buprenorphine is a Schedule III partial μ-opioid receptor agonist that is an equally effective but potentially safer treatment option for chronic pain than full μ-opioid receptor agonists. 5mg was found to be 30. Both the full opioid agonist methadone (MET) and the partial agonist buprenorphine (BUP) are licensed for the treatment of opioid dependence. Numerous clinical studies and randomized clinical trials have demonstrated buprenorphine's efficacy in retaining patients in treatment and reducing illicit opioid use compared with treatment without medication and medically supervised withdrawal. Buprenorphine (Belbuca) is a controlled substance. Guidelines produced by a committee of professionals led by TDMHSAS and the Tennessee Department of Health on prescribing buprenorphine in non-residential settings. Tell your doctor if any of these symptoms are severe or do not go away: difficulty falling asleep or staying asleep. DPT@SAMHSA. Official answer. 4. The drug is long-acting, works slowly, and, similar to methadone, helps prevent the intense cravings and with-drawal symptoms associated with opioid use. Select a state from the map or use the dropdown lists to view practitioners by city, state or zip. Call your doctor for medical advice about side effects. Buprenorphine used to treat opioid use disorder works by partially activating opioid receptors in the brain, which can help reduce opioid cravings, withdrawal, and overall use of other opioids. 10. com. SMA15-4442. Emergency departments (EDs) offer an. Common Subutex side effects may include: constipation, nausea, vomiting; headache; increased sweating; sleep problems ( insomnia ); or. 800. 2014; 8:176–182. [Google Scholar] Mattick RP, Ali R, White JM, O'Brien S, Wolk S, Danz C. CHAllenges in Managing and Preventing Pain (CHAMPP) 230 McKee Place, Suite 600 Pittsburgh, PA 15213 CHAMPP@pitt. However, there is a lack of foundational theory and empirical data to guide clinicians in evaluating such novel induction strategies. Buprenorphine belongs to a class of drugs called mixed opioid agonist-antagonists. Women presenting prior. Buprenorphine is used to treat addiction to opioid drugs (such as heroin) and narcotic painkillers. As a high-affinity, partial agonist for the mu-opioid receptor, buprenorphine suppresses opioid withdrawal and craving, reduces illicit opioid use, and blocks exogenous opioid effects including respiratory depression. The only opioid agonists approved for the treatment of OUD in the United States are methadone and buprenorphine. SUBLINGUAL Tablets: Following a 2-day induction: Adjust dose in 2 to 4 mg increments/decrements to a level that holds patient in treatment and suppresses opioid withdrawal signs and symptoms. The symptoms can vary in severity and duration, depending on how long users have been taking Suboxone, as well as the dosage of the drug. [2] In rats, unlike buprenorphine, norbuprenorphine produces marked respiratory depression but with very little antinociceptive effect. You may report side effects to FDA at 1-800-FDA-1088. The file is intended solely for research, analytic purposes, population-based. headache. Medicare drug coverage (Part D) also covers drugs like buprenorphine (to treat opioid use disorders) and methadone (when prescribed for pain). Buprenorphine will make most other opioids ineffective during and after surgery. Buprenorphine is an opioid that works by changing the way the brain and nervous system respond to pain. The safe use of buprenorphine requires close communication with your healthcare provider. Individuals who had at least 3 visits to our colocated clinic were included in the analysis. labeling, take home doses)? 6. Annemarie Jones, Nurse Unit Manager, Kempsey Opioid Substitution Treatment Clinic, Mid North Coast Local Health District Debbie Kaplan, Manager, Clinical Policy, Alcohol and Other Drugs, Centre for Population Health,. 71. Make the process simple. 1636-1644. They can also help reduce drug cravings. Buprenorphine or methadone can be administered without registration as a narcotic treatment program under T itle 21, Code of Federal Regulations, Part 1306. And this dose is given by either IV or IM injection once every 4 to 6 hours. This type of treatment can lead to more favorable outcomes. Drug overdose deaths among pregnant and postpartum people soared significantly between 2018 and 2021, according to a report published Wednesday. 2 Program in Addiction Medicine, Department of Medicine, Yale School of Medicine, New Haven, Connecticut, USA. Akron Suboxone Doctor is committed to providing high-quality care to those struggling with. It is also used to treat pain. We’ve helped thousands on their recovery journey. Gov. Our $100,000 challenge is underway. Clin Pharmacol Ther. Buprenorphine Extended-Release (Bup ER) is a patented compounded opioid that provides up to 48 hours of analgesia and is only available by prescription from a. The drug is used to relieve pain and increase feelings of euphoria in cats. It is also an antagonist at the kappa -opioid receptor, which means it blocks this receptor which may play a role in opioid. Morphine has an average rating of 7. email. This medication contains 2 medicines: buprenorphine and naloxone. We do not endorse non-Cleveland Clinic products or services. A patient returns to the outpatient clinic for follow-up of buprenorphine treatment of opioid use disorder. 20. Medications for Substance Use Disorder Treatment Services Locators. (link sends email) For more information about OTP certification and opening a treatment program, contact your states OTP Compliance Officer. upset. Price decreased 3. iAgencies release guidance on buprenorphine prescribing. 71 mg. [14] It can be used under the tongue (sublingual), in the cheek (buccal), by injection ( intravenous and subcutaneous ), as a skin patch (transdermal), or as an implant. admission or in-clinic observation for close monitoring of the buprenorphine induction process (see sample inpatient buprenorphine induction policy). Book an appointment today!Buprenorphine demonstrates slow dissociation kinetics (~166 min), which contributes to its long duration of action and allows for once-daily or even every-second-day dosing. Adult: 0. The aim of this study is to compare health outcomes in opioid dependent patients treated with BUP and BUP-NLX. Buprenorphine skin patch is used to treat moderate to severe chronic pain when around-the-clock pain relief is needed for a long period of time. Muscle and body aches. The transdermal patch and buccal film are. Buprenorphine skin patches are packaged in sealed pouches. 1177/0269881118756015. The recommended dosage of. 7 mg buprenorphine with 0. 1 cc DexdomitorAdminister 8 to 24 mg of Suboxone® every 30-60 minutes with a maximum total BUP dose of ≤32 mg Buprenorphine should not be expected to cover acute pain needs in addition to the patients known opioid debt so resuming a full-agonist is reasonable Justin Time (35/M) Hydromorphone PCA 0. Timing a change of opioid formulation and/or route of administration 14 References 15Buprenorphine is a partial opioid agonist, which means that it does not have the full effect of other semi-synthet-ic opioids in the same class, such as heroin or oxycodo-ne. Buprenorphine is not the same as Suboxone; Suboxone is a two-ingredient drug used to treat opioid dependence. < 11. Buprenorphine is a partial mu-opioid receptor agonist with lower potential for misuse and overdose compared with the full mu-opioid receptor agonist methadone. Get. JAMA, 313(16), pp. 15. 1 mg buprenorphine with 0. 3259 [email protected] mildly inhibits cardiac repolarization. com. Buprenorphine dose and dosing frequency should be individualized based on patients' treatment needs, the possibility of novel components in the drug supply should be considered during OUD treatment, and all forms of opioid agonist treatment should be offered and considered for patients. Buprenorphine HCl/Naloxone HCl Sublingual Tablets [prescribing information]. At initiation of buprenorphine treatment, approximately 21% (1,343 patients) were prescribed 8 mg, 50% (3,264 patients) 16 mg, and 10% (668 patients) 24 mg. A cat who has suffered a severe trauma or dramatic physical injuries is a potential subject for buprenorphine treatment. For assistance with the Opioid Treatment Program Extranet, contact the OTP helpdesk at [email protected] mg naloxone, 6. People as young as 16 may use Suboxone. Zubsolv®. Pain, itching, or redness at the injection site may also occur. As well as improving wellbeing by preventing physical withdrawal, pharmacotherapy helps to. Food and Drug Administration approved Brixadi (buprenorphine) extended-release injection for subcutaneous use (under the skin) to. 10-3 Effective: November 1, 2019 Related medical policies: • Sublocade (65. The usual dose is 2 to 6 micrograms (mcg) of drug per kilogram (kg) of body weight. When a patient is pregnant; 2. Find top doctors who treat Buprenorphine Suboxone Addiction near you in Akron, OH. buprenorphine binds more avidly to opioid receptors than most opioids, pain control with other mu agonists requires careful attention and titration. However, strong opioids are ineffective as pain treatment in all patients and are not well-tolerated by all patients. Buprenorphine alone or with naloxone: Which is safer? 10. g. It's considered a partial opioid because it causes an opposite effect when it binds to delta and kappa-opioid receptors, which may help prevent medication misuse and dependence. doi: 10. Medical policy no. Rahul Gupta, the director of the White House’s Office of National Drug Control Policy, said in an interview that about 130,000 health. 36 mg naloxone, 2. Advertising on our site helps support our mission. To prevent constipation, eat dietary fiber, drink. The Substance Abuse and Mental Health Services Administration (SAMHSA) also has a treatment locator at 1-866-287-2728. August 2015. Norbuprenorphine is a major active metabolite of the opioid modulator buprenorphine. Cleveland Clinic is a non-profit academic medical center. It works by blocking pain signals in the brain. 20. 5 QTc prolongation has been observed in clinical studies for dosages of transdermal buprenorphine two 20 mcg/hr patches and buprenorphine buccal film up to 900 mcg every 12 hours. (2021). How to store Espranor. An analgesic is a drug that is used to relieve pain. The lowest BuTrans dose (BuTrans 5 microgram/hour transdermal patch) should be used as the initial dose. Introduction. Do you follow the same rules for dispensing buprenorphine as you would for dispensing methadone through a methadone clinic (e. Get buprenorphine for as low as $35. Buprenorphine is a mixed agonist-antagonist with high affinity at both mu and kappa opiate receptors. Each buprenorphine injection slowly releases the drug into your body over a. But, some people might need to use it for a longer period of time. This combination is designed to discourage abuse of buprenorphine, as naloxone can precipitate withdrawal symptoms in patients with OUD. It is available in both brand and generic versions. doi: 10. Patients aged 18 years and over. Home Buprenorphine Initiation. The 8-hour opioid or other substance use disorders training activities below (along with the other pathways) meet the Federal training requirement of the 2022 Medication Access and Training Expansion (MATE) Act. 2. Office-based treatment for opioid addiction. Results. We investigated the efficacy of adding buprenorphine in reducing METH cravings during treatment with the Matrix program. A buprenorphine patch is an opioid medication that treats severe, chronic pain by blocking pain signals in your brain. Buprenorphine is used in medication-assisted treatment (MAT) to help people reduce or quit their use of heroin or other opiates, such as pain relievers like morphine. All NPs and PAs are knowingly subject to theOpioids (excluding Buprenorphine) Buprenorphine Current Qty Current mg/day 30 Day Avg mg/day 48 2. Buprenorphine is a generic prescription drug classified as a partial opioid agonist. The drug is called buprenorphine. It is a μ-opioid, δ-opioid, and nociceptin receptor full agonist, [1] [2] and a κ-opioid receptor partial agonist. S. It activates the same receptors in your body that opioid drugs such as heroin, fentanyl, and oxycodone do. Opioid Treatment Program Contacts. These receptors are responsible for pain relief. Suite A. Immunoassay often does not detect BPN and gas chromatography-mass spectrometry (GC-MS) is needed. Overdose with buprenorphine in adults is less common, and most likely occurs in individuals without tolerance, or who are using co-occurring substances like alcohol or. 66% of reviewers reported a positive effect, while 14% reported a negative. 1093/pm/pnz356. We are here to listen and support your road to recovery. Buprenorphine. The aim of the study was to compare buprenorphine's behaviour with respect to the occurrence of ceiling (or apparent maximum) in these. It may also be called an opioid analgesic. Drawing on archival research, document analysis, and interviews with. During the study period, the mobile clinic served 569 people—of these, about 74% received prescriptions for buprenorphine and 70% were tested for at least. In France, family physicians prescribe buprenorphine to 65 000 patients, whereas specialized clinics prescribe methadone to only 6000 to 7000 patients. It is also used to treat pain. Buprenorphine possesses many unique attributes that make it a practical agent for adults and adolescents with opioid use disorder (OUD) and/or acute or chronic pain. Buprenorphine/naloxone combinations were on average 19. 2 mg q10 minutes Herring, A. . Yngvild Olsen, Director of SAMHSA’s Center for Substance Abuse Treatment joined the American Academy of Addiction Psychiatry (AAAP) to discuss the new requirements per the Consolidated Appropriations Act, 2023 or MAT (Section 1262) and MATE Act (Section 1263) effective as of June 27, 2023, and what clinicians should know. Buprenorphine/naloxone is a combination opioid medication that works well to treat opioid dependence. Suboxone (buprenorphine/naloxone) [Canadian product monograph]. Nausea and vomiting. The effects of buprenorphine last for 24 to 36 hours. 2)]. doi: 10. 00. A 2020 Department of Health and Human Services Office of Inspector General report found 40% of U. stomach pain or tenderness. Treatment with buprenorphine. One woman's controversial fight to make America accept drug users for who they are. The number of months of buprenorphine treatment per 1,000 people increased from 1. buprenorphine will generally be too weak to prevent withdrawal symptoms and is best used for patients with chronic pain. 17 Buprenorphine jobs available in Worldwide USA on Indeed. It is available in a number of dosage forms under the brand names Belbuca, Brixadi, Buprenex, Butrans, Probuphine (discontinued), Sublocade, and Subutex (discontinued). 5mg and 8/2mg sublingual film Subutex® contains. 01 and 0. Results. Anthony R. Target dose: 16 mg sublingually once a day; range 4 to 24 mg/day. 1093/fampra/cmab073. Usually, the maintenance dose for pain management is between 0. Federal law (DEA Diversion Control Division 72-hour exception) allows a physician to administer methadone or buprenorphine, once a day, for up to a 72-hour period, in the case of an emergency, while a connection to addiction treatment is made. 18 mg naloxone, 1. It also stays attached to those receptors for longer, which means it has a prolonged effect. The purpose of this study was to characterize the acute effects of buprenorphine, an opioid partial mu-agonist, across a wide range of doses in comparison to methadone. The medication is available as a tablet or film that's either dissolved under your tongue or against the inside of your cheek. Buprenorphine undergoes extensive first-pass metabolism and therefore has very low oral bioavailability. The naloxone in Suboxone blocks the effects of opioid overdose, preventing abuse. Administer 8 to 24 mg of Suboxone® every 30-60 minutes with a maximum total BUP dose of ≤32 mg Buprenorphine should not be expected to cover acute pain needs in addition to the patients known opioid debt so resuming a full-agonist is reasonable Justin Time (35/M) Hydromorphone PCA 0. In many cases, mild side effects from the drug can be temporary. 6. Select a state from the map or use the dropdown lists to view practitioners by city, state or zip code who previously held a DATA-2000 waiver to prescribe buprenorphine for the treatment of opioid use disorder (OUD). Compton, MD, MPE, Office of the Director, National Institute on Drug Abuse, 301 N Stonestreet Ave, 3WFN Room 09D18, MSC 6025, Bethesda, MD 20892-6025 ( [email protected] buprenorphine side effects may be more likely to occur, such as: constipation, nausea, vomiting; headache; increased sweating; sleep problems (. Buprenorphine belongs to the class of medicines known as narcotic analgesics. Dr. 2 Patients and clinicians have raised concerns that individuals using fentanyl may. Each listing includes contact information (address, phone number, website). Buprenorphine acts on the central nervous system (CNS) to relieve pain. Ste. Buprenorphine, fentanyl and morphine are examples of strong opioids used for cancer pain relief. Buprenorphine, an oripavine derivative, is used clinically for pain management [21,74]. 71. Buprenorphine, a semi-synthetic opioid, was first developed in the 1970s as an analgesic with parenteral. But if side effects last for a longer time, or if they bother. Both the full opioid agonist methadone (MET) and the partial agonist buprenorphine (BUP) are licensed for the treatment of opioid dependence. The new Practice Guidelines for the Administration of. QUICK START GUIDE &ª»±¾Ès«È I± «È ȱ. buprenorphine: [noun] a semisynthetic narcotic analgesic that is administered in the form of its hydrochloride C29H41NO4·HCl to control moderate to severe pain and treat opioid dependence #R##N##R##N# Note:#R##N# Buprenorphine is administered by injection to control pain, is used in the form of a transdermal. Sublingual buprenorphine is a tablet which you put under your tongue. Boas RA, Villiger JW. Usually, the maintenance dose for pain management is between 0. Double my gift. Using the transdermal (skin) patch form, buprenorphine stays in the system for about 130 hours (about 5 to 6 days). 5 mg, and • buprenorphine/naloxone 8 mg/2 mg. 1 mg buprenorphine with 0. In 2016, there were 42,249 opioid-overdose deaths in the United States, a 28% increase from the previous year. Dr. Buprenorphine injection is used to relieve moderate to severe pain. Medicare Part A (Hospital Insurance) covers methadone when it’s used to treat an opioid use disorder as a hospital inpatient. Its pharmacological profile is determined primarily by partial agonism at mu-receptors and unusually slow kinetics at these receptors. If you find shaving easier, shave the area a few days before you apply the patch to make sure shaving does not irritate your skin. Check Insurance Online. pain in the abdomen, back, arms, legs, joints and muscles, leg cramps, muscle weakness. Our goal is to help our patients recover and live healthy, productive lives. 36 mg naloxone, 2. Myth #2: People frequently misuse Suboxone. 3408 Babcock Blvd. While Suboxone is regarded by some as the future of medical treatment, others have expressed concerns. We reviewed the medical records of 281 patients living in halfway houses and treated at an office-based buprenorphine MAT clinic following a diagnosis of OUD between July 1, 2018 and June 30, 2019. Buprenorphine is a first-line treatment for opioid use disorder (OUD) that decreases all-cause mortality [] and expansion of buprenorphine treatment is associated with a decline in heroin overdose deaths []. Buprenorphine has a half-life of 24–60 h with other clinical effects such as analgesia and euphoria lasting at least 6 h. S. Mattick RP, Breen C, Kimber J, Davoli M. 4 CONTRAINDICATIONS . : Buprenorphine is an effective treatment for opioid use disorder. Buprenorphine is not the same as Suboxone; Suboxone is a two-ingredient drug used to treat opioid dependence. To address concerns regarding the intravenous diversion of buprenorphine, a combined buprenorphine-naloxone (BUP-NLX) preparation was developed. Reality: Suboxone, like any opiate, and many other medications, can be misused. Take the first step. Your likelihood of experiencing side effects may depend on: if you regularly use buprenorphine. Buprenorphine comes in different forms, including under-the-tongue products, skin patches, and injections. Opioid Treatment Program Contacts. It is very important to keep all Suboxone/buprenorphine away from babies and small children, and call 911 if they accidently taste or swallow some. Deaths from opioid-related overdose have remained at epidemic levels for more than a decade without a clear solution in reach. Buprenorphine (Butrans) is an expensive drug used to treat moderate to severe pain. And while buprenorphine — often referred to by a common brand name, Suboxone — can be prescribed by any doctor, it is increasingly. 5 out of 10 from a total of 371 ratings on Drugs. Recovery is possible and Cleveland Clinic Akron General Alcohol. Spero Health Akron, Ohio Addiction Treatment. Check Insurance Online. After putting the lives of thousands of addicts back on track over a period of 32 years, the Gurdaspur Red Cross De-addiction Centre is on the verge of closure following an acute shortage. Therefore, continuation of once-daily outpatient dosing for OUD alone is not sufficient for acute pain management. Cochrane Database of Systematic Reviews 2014,. Buprenorphine can be initiated in untreated patients with OUD and acute pain in the perioperative setting to decrease the risk of opioid recurrence and death from overdose. Following sublingual (under the tongue) administration buprenorphine stays in the system for. In order to curb the abuse potential of this drug, many treatment centers and prisons crush Subutex tablets before administering them to patients. Buprenorphine. [Brown University] — A study from researchers at Brown University, Rhode Island Hospital and the University of Rhode Island found that pharmacists — not just physicians at clinics and doctor’s offices — can safely and effectively start patients with opioid use disorder on the lifesaving medication. The most common medication for opioid use disorder will soon be buprenorphine. ACTION: Notice. 6 million Americans have opioid use disorder (OUD), and the overdose crisis has worsened over the past several years, with preliminary data from 2019 and 2020 indicating that opioid overdose death rates are climbing. There is pre-clinical evidence to support the claim that naloxone has very limited effects when buprenorphine is present. January 3, 2018. Bunavail®. Buprenorphine is a partial opioid agonist commonly used to treat opioid dependence. Managing opioid withdrawal precipitated by buprenorphine with buprenorphine. Buprenorphine is a common medication used to treat opioid use disorder. If any of these effects last or get worse, tell your doctor or pharmacist right away. A list of Suboxone (buprenorphine) prescribers and treatment programs in Iowa. It is prescribed when other pain medications have not worked or cannot be tolerated. This resource provides information to primary care providers and practices on how to implement opioid use disorder treatment using buprenorphine. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins. Akron, OH 44305 (330) 434-4141 Saint Thomas Hospital - Ignatia Hall 444 North Main Street Akron, OH 44310. Buprenor-a 30-day supply of buprenorphine for the treatment of opioid use disorder. aBuprenorphine mildly inhibits cardiac repolarization. Buprenorphine works in a way that may also make it helpful for treating chronic pain. HHS. Gov. Buprenorphine without naloxone (buprenorphine mono-product) shall not be prescribed except: [email protected] our data, buprenorphine plasma concentrations measured in the study were similar to those reported by Al-Tawil et al. But it doesn’t activate them as strongly as. Analgesics, Opioid. Recovery is possible and Cleveland Clinic Akron General Alcohol and Drug Recovery Center offers help and guidance. Section 1262 of the Consolidated Appropriations Act, 2023 (also known as Omnibus bill), removes the federal requirement for practitioners to have a DATA 2000 waiver (“x-waiver”) or submit a Notice of Intent to prescribe medications, like buprenorphine, for the treatment of opioid use disorder (OUD). Since they contain no opioids, any doctor can prescribe these medications. 6 Cohort studies and controlled trials have demonstrated that buprenorphine treatment of opioid addiction is safe and effective when prescribed by primary care physicians in community settings. Drowsiness, dizziness, constipation, or headache may occur. As a high affinity, partial agonist for the mu opioid receptor, buprenorphine suppresses opioid withdrawal and craving, reduces illicit opioid use, and blocks exogenous opioid effects including respiratory depression. Contact Us. Suboxone, a branded version of buprenorphine and naloxone, is used to treat opioid addiction. 75 hours. 07(b) 1Buprenorphine was rapidly absorbed into plasma after injection of 0. Call your doctor for medical advice about side effects.